This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TLR5-20-RE | 20 (40 μL) | 200 μL |  |
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| TLR5-20-OR | 20 (40 μL) | 200 μL |  |
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| TLR5-20-GO | 20 (40 μL) | 200 μL |  |
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| TLR5-20-GR | 20 (40 μL) | 200 μL |  |
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| TLR5-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
Gene Symbol : TLR5
Gene Name : Toll like receptor 5
Chromosome : CHR 1: 223,143,281-223,108,400
Locus : 1q41
Alt. Genes : OPTN
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