This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TMEM173-20-RE | 20 (40 μL) | 200 μL |  |
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| TMEM173-20-OR | 20 (40 μL) | 200 μL |  |
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| TMEM173-20-GO | 20 (40 μL) | 200 μL |  |
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| TMEM173-20-GR | 20 (40 μL) | 200 μL |  |
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| TMEM173-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Gene Symbol : TMEM173
Gene Name : Transmembrane protein 173
Chromosome : CHR 5: 139,482,789-139,475,527
Locus : 5q31.2
Alt. Genes : OPTN
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