The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. [provided by RefSeq, Oct 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TMEM189-UBE2V1-20-RE | 20 (40 μL) | 200 μL |  |
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| TMEM189-UBE2V1-20-OR | 20 (40 μL) | 200 μL |  |
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| TMEM189-UBE2V1-20-GO | 20 (40 μL) | 200 μL |  |
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| TMEM189-UBE2V1-20-GR | 20 (40 μL) | 200 μL |  |
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| TMEM189-UBE2V1-20-AQ | 20 (40 μL) | 200 μL |  |
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The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. [provided by RefSeq, Oct 2010]
Gene Symbol : TMEM189-UBE2V1
Gene Name : TMEM189-UBE2V1 readthrough
Chromosome : CHR 20: 501,537,97-500,811,23
Locus : 20q13.13
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