The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TNFRSF10B-20-RE | 20 (40 μL) | 200 μL |  |
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| TNFRSF10B-20-OR | 20 (40 μL) | 200 μL |  |
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| TNFRSF10B-20-GO | 20 (40 μL) | 200 μL |  |
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| TNFRSF10B-20-GR | 20 (40 μL) | 200 μL |  |
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| TNFRSF10B-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Symbol : TNFRSF10B
Gene Name : TNF receptor superfamily member 10b
Chromosome : CHR 8: 230,691,86-230,201,32
Locus : 8p21.3
Alt. Genes : PIAS3
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