The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TNFRSF11B-20-RE | 20 (40 μL) | 200 μL |  |
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| TNFRSF11B-20-OR | 20 (40 μL) | 200 μL |  |
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| TNFRSF11B-20-GO | 20 (40 μL) | 200 μL |  |
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| TNFRSF11B-20-GR | 20 (40 μL) | 200 μL |  |
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| TNFRSF11B-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Symbol : TNFRSF11B
Gene Name : TNF receptor superfamily member 11b
Chromosome : CHR 8: 118,952,143-118,923,556
Locus : 8q24.12
Alt. Genes : ARPC2
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