This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TNFRSF18-20-RE | 20 (40 μL) | 200 μL |  |
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| TNFRSF18-20-OR | 20 (40 μL) | 200 μL |  |
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| TNFRSF18-20-GO | 20 (40 μL) | 200 μL |  |
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| TNFRSF18-20-GR | 20 (40 μL) | 200 μL |  |
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| TNFRSF18-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
Gene Symbol : TNFRSF18
Gene Name : TNF receptor superfamily member 18
Chromosome : CHR 1: 120,789,9-120,350,7
Locus : 1p36.33
Alt. Genes : SERF2
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