The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TNFRSF4-20-RE | 20 (40 μL) | 200 μL |  |
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| TNFRSF4-20-OR | 20 (40 μL) | 200 μL |  |
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| TNFRSF4-20-GO | 20 (40 μL) | 200 μL |  |
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| TNFRSF4-20-GR | 20 (40 μL) | 200 μL |  |
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| TNFRSF4-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
Gene Symbol : TNFRSF4
Gene Name : TNF receptor superfamily member 4
Chromosome : CHR 1: 121,681,1-121,132,5
Locus : 1p36.33
Alt. Genes : SERF2
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