The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TNFRSF8-20-RE | 20 (40 μL) | 200 μL |  |
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| TNFRSF8-20-OR | 20 (40 μL) | 200 μL |  |
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| TNFRSF8-20-GO | 20 (40 μL) | 200 μL |  |
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| TNFRSF8-20-GR | 20 (40 μL) | 200 μL |  |
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| TNFRSF8-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Symbol : TNFRSF8
Gene Name : TNF receptor superfamily member 8
Chromosome : CHR 1: 120,633,17-121,442,12
Locus : 1p36.22
Alt. Genes : PDZK1IP1
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