This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TOP1MT-20-RE | 20 (40 μL) | 200 μL |  |
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| TOP1MT-20-OR | 20 (40 μL) | 200 μL |  |
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| TOP1MT-20-GO | 20 (40 μL) | 200 μL |  |
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| TOP1MT-20-GR | 20 (40 μL) | 200 μL |  |
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| TOP1MT-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Gene Symbol : TOP1MT
Gene Name : DNA topoisomerase I mitochondrial
Chromosome : CHR 8: 143,359,976-143,309,323
Locus : 8q24.3
Alt. Genes : CALCRL
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