This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TP53BP1-20-RE | 20 (40 μL) | 200 μL |  |
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| TP53BP1-20-OR | 20 (40 μL) | 200 μL |  |
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| TP53BP1-20-GO | 20 (40 μL) | 200 μL |  |
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| TP53BP1-20-GR | 20 (40 μL) | 200 μL |  |
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| TP53BP1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Gene Symbol : TP53BP1
Gene Name : Tumor protein p53 binding protein 1
Chromosome : CHR 15: 435,105,08-434,030,63
Locus : 15q15.3
Alt. Genes : LRPPRC
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