This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TPMT-20-RE | 20 (40 μL) | 200 μL |  |
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| TPMT-20-OR | 20 (40 μL) | 200 μL |  |
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| TPMT-20-GO | 20 (40 μL) | 200 μL |  |
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| TPMT-20-GR | 20 (40 μL) | 200 μL |  |
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| TPMT-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
Gene Symbol : TPMT
Gene Name : Thiopurine S-methyltransferase
Chromosome : CHR 6: 181,551,64-181,283,10
Locus : 6p22.3
Alt. Genes : ZNF263
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