The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TRIM5-20-RE | 20 (40 μL) | 200 μL |  |
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| TRIM5-20-OR | 20 (40 μL) | 200 μL |  |
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| TRIM5-20-GO | 20 (40 μL) | 200 μL |  |
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| TRIM5-20-GR | 20 (40 μL) | 200 μL |  |
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| TRIM5-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]
Gene Symbol : TRIM5
Gene Name : Tripartite motif containing 5
Chromosome : CHR 11: 568,510,8-559,090,5
Locus : 11p15.4
Alt. Genes : PTGS1
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