This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TRIOBP-20-RE | 20 (40 μL) | 200 μL |  |
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| TRIOBP-20-OR | 20 (40 μL) | 200 μL |  |
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| TRIOBP-20-GO | 20 (40 μL) | 200 μL |  |
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| TRIOBP-20-GR | 20 (40 μL) | 200 μL |  |
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| TRIOBP-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]
Gene Symbol : TRIOBP
Gene Name : TRIO and F-actin binding protein
Chromosome : CHR 22: 376,969,87-377,765,55
Locus : 22q13.1
Alt. Genes : CLEC3A
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