This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TRIP4-20-RE | 20 (40 μL) | 200 μL |  |
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| TRIP4-20-OR | 20 (40 μL) | 200 μL |  |
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| TRIP4-20-GO | 20 (40 μL) | 200 μL |  |
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| TRIP4-20-GR | 20 (40 μL) | 200 μL |  |
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| TRIP4-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016]
Gene Symbol : TRIP4
Gene Name : Thyroid hormone receptor interactor 4
Chromosome : CHR 15: 643,878,03-644,553,02
Locus : 15q22.31
Alt. Genes : FEM1B
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