This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome. [provided by RefSeq, May 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TRMT1-20-RE | 20 (40 μL) | 200 μL |  |
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| TRMT1-20-OR | 20 (40 μL) | 200 μL |  |
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| TRMT1-20-GO | 20 (40 μL) | 200 μL |  |
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| TRMT1-20-GR | 20 (40 μL) | 200 μL |  |
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| TRMT1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome. [provided by RefSeq, May 2017]
Gene Symbol : TRMT1
Gene Name : TRNA methyltransferase 1
Chromosome : CHR 19: 131,175,67-131,048,99
Locus : 19p13.13
Alt. Genes : OPTN
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