This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TRMU-20-RE | 20 (40 μL) | 200 μL |  |
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| TRMU-20-OR | 20 (40 μL) | 200 μL |  |
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| TRMU-20-GO | 20 (40 μL) | 200 μL |  |
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| TRMU-20-GR | 20 (40 μL) | 200 μL |  |
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| TRMU-20-AQ | 20 (40 μL) | 200 μL |  |
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This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Symbol : TRMU
Gene Name : TRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
Chromosome : CHR 22: 463,354,00-463,573,39
Locus : 22q13.31
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