The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TSG101-20-RE | 20 (40 μL) | 200 μL |  |
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| TSG101-20-OR | 20 (40 μL) | 200 μL |  |
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| TSG101-20-GO | 20 (40 μL) | 200 μL |  |
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| TSG101-20-GR | 20 (40 μL) | 200 μL |  |
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| TSG101-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]
Gene Symbol : TSG101
Gene Name : Tumor susceptibility 101
Chromosome : CHR 11: 185,269,55-184,803,10
Locus : 11p15.1
Alt. Genes : RBM12
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