This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the pan-hematopoietic expression gene (PHEMX), escapes imprinting. This gene may play a role in malignancies and disease that involve this region. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TSSC4-20-RE | 20 (40 μL) | 200 μL |  |
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| TSSC4-20-OR | 20 (40 μL) | 200 μL |  |
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| TSSC4-20-GO | 20 (40 μL) | 200 μL |  |
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| TSSC4-20-GR | 20 (40 μL) | 200 μL |  |
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| TSSC4-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the pan-hematopoietic expression gene (PHEMX), escapes imprinting. This gene may play a role in malignancies and disease that involve this region. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Symbol : TSSC4
Gene Name : Tumor suppressing subtransferable candidate 4
Chromosome : CHR 11: 240,040,8-240,387,7
Locus : 11p15.5
Alt. Genes : YAF2
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