This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TUBGCP4-20-RE | 20 (40 μL) | 200 μL |  |
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| TUBGCP4-20-OR | 20 (40 μL) | 200 μL |  |
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| TUBGCP4-20-GO | 20 (40 μL) | 200 μL |  |
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| TUBGCP4-20-GR | 20 (40 μL) | 200 μL |  |
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| TUBGCP4-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Gene Symbol : TUBGCP4
Gene Name : Tubulin gamma complex associated protein 4
Chromosome : CHR 15: 433,710,58-434,097,70
Locus : 15q15.3
Alt. Genes : SGK2
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