This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TXNDC5-20-RE | 20 (40 μL) | 200 μL |  |
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| TXNDC5-20-OR | 20 (40 μL) | 200 μL |  |
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| TXNDC5-20-GO | 20 (40 μL) | 200 μL |  |
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| TXNDC5-20-GR | 20 (40 μL) | 200 μL |  |
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| TXNDC5-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]
Gene Symbol : TXNDC5
Gene Name : Thioredoxin domain containing 5
Chromosome : CHR 6: 791,081,3-788,124,9
Locus : 6p24.3
Alt. Genes : ARPC2
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