This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TYK2-20-RE | 20 (40 μL) | 200 μL |  |
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| TYK2-20-OR | 20 (40 μL) | 200 μL |  |
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| TYK2-20-GO | 20 (40 μL) | 200 μL |  |
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| TYK2-20-GR | 20 (40 μL) | 200 μL |  |
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| TYK2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Gene Symbol : TYK2
Gene Name : Tyrosine kinase 2
Chromosome : CHR 19: 103,805,71-103,505,27
Locus : 19p13.2
Alt. Genes : ZNF263
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