The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| UBE2L3-20-RE | 20 (40 μL) | 200 μL |  |
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| UBE2L3-20-OR | 20 (40 μL) | 200 μL |  |
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| UBE2L3-20-GO | 20 (40 μL) | 200 μL |  |
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| UBE2L3-20-GR | 20 (40 μL) | 200 μL |  |
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| UBE2L3-20-AQ | 20 (40 μL) | 200 μL |  |
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Symbol : UBE2L3
Gene Name : Ubiquitin conjugating enzyme E2 L3
Chromosome : CHR 22: 215,494,46-216,240,33
Locus : 22q11.21
Alt. Genes : TRAP1
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