The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| UBR1-20-RE | 20 (40 μL) | 200 μL |  |
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| UBR1-20-OR | 20 (40 μL) | 200 μL |  |
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| UBR1-20-GO | 20 (40 μL) | 200 μL |  |
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| UBR1-20-GR | 20 (40 μL) | 200 μL |  |
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| UBR1-20-AQ | 20 (40 μL) | 200 μL |  |
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The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]
Gene Symbol : UBR1
Gene Name : Ubiquitin protein ligase E3 component n-recognin 1
Chromosome : CHR 15: 431,060,87-429,428,96
Locus : 15q15.2
Alt. Genes : FEM1B
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