This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| UMPS-20-RE | 20 (40 μL) | 200 μL |  |
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| UMPS-20-OR | 20 (40 μL) | 200 μL |  |
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| UMPS-20-GO | 20 (40 μL) | 200 μL |  |
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| UMPS-20-GR | 20 (40 μL) | 200 μL |  |
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| UMPS-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Symbol : UMPS
Gene Name : Uridine monophosphate synthetase
Chromosome : CHR 3: 124,730,365-124,749,272
Locus : 3q21.2
Alt. Genes : RBM12
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