This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| UNC45B-20-RE | 20 (40 μL) | 200 μL |  |
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| UNC45B-20-OR | 20 (40 μL) | 200 μL |  |
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| UNC45B-20-GO | 20 (40 μL) | 200 μL |  |
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| UNC45B-20-GR | 20 (40 μL) | 200 μL |  |
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| UNC45B-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Gene Symbol : UNC45B
Gene Name : Unc-45 myosin chaperone B
Chromosome : CHR 17: 351,477,92-351,893,44
Locus : 17q12
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