This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| UNG-20-RE | 20 (40 μL) | 200 μL |  |
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| UNG-20-OR | 20 (40 μL) | 200 μL |  |
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| UNG-20-GO | 20 (40 μL) | 200 μL |  |
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| UNG-20-GR | 20 (40 μL) | 200 μL |  |
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| UNG-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
Gene Symbol : UNG
Gene Name : Uracil DNA glycosylase
Chromosome : CHR 12: 109,097,593-109,110,992
Locus : 12q24.11
Alt. Genes : FEM1B
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