USP18 FISH Probe

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
USP18-20-RE 20 (40 μL) 200 μL color Request Pricing
USP18-20-OR 20 (40 μL) 200 μL color Request Pricing
USP18-20-GO 20 (40 μL) 200 μL color Request Pricing
USP18-20-GR 20 (40 μL) 200 μL color Request Pricing
USP18-20-AQ 20 (40 μL) 200 μL color Request Pricing

Gene Summary

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]

Gene Details

Gene Symbol : USP18

Gene Name : Ubiquitin specific peptidase 18

Chromosome : CHR 22: 181,499,58-181,773,96

Locus : 22q11.21

Alt. Genes : ATP6AP2

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