Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| USP5-20-RE | 20 (40 μL) | 200 μL |  |
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| USP5-20-OR | 20 (40 μL) | 200 μL |  |
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| USP5-20-GO | 20 (40 μL) | 200 μL |  |
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| USP5-20-GR | 20 (40 μL) | 200 μL |  |
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| USP5-20-AQ | 20 (40 μL) | 200 μL |  |
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Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]
Gene Symbol : USP5
Gene Name : Ubiquitin specific peptidase 5
Chromosome : CHR 12: 685,211,7-686,663,1
Locus : 12p13.31
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