This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| UVRAG-20-RE | 20 (40 μL) | 200 μL |  |
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| UVRAG-20-OR | 20 (40 μL) | 200 μL |  |
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| UVRAG-20-GO | 20 (40 μL) | 200 μL |  |
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| UVRAG-20-GR | 20 (40 μL) | 200 μL |  |
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| UVRAG-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
Gene Symbol : UVRAG
Gene Name : UV radiation resistance associated
Chromosome : CHR 11: 758,148,51-761,442,37
Locus : 11q13.5
Alt. Genes : LRPPRC
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