VRK1 FISH Probe

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
VRK1-20-RE 20 (40 μL) 200 μL color Request Pricing
VRK1-20-OR 20 (40 μL) 200 μL color Request Pricing
VRK1-20-GO 20 (40 μL) 200 μL color Request Pricing
VRK1-20-GR 20 (40 μL) 200 μL color Request Pricing
VRK1-20-AQ 20 (40 μL) 200 μL color Request Pricing

Gene Summary

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol : VRK1

Gene Name : Vaccinia related kinase 1

Chromosome : CHR 14: 967,973,08-968,816,13

Locus : 14q32.2

Alt. Genes : ARL4C

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