This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ZAP70-20-RE | 20 (40 μL) | 200 μL |  |
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| ZAP70-20-OR | 20 (40 μL) | 200 μL |  |
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| ZAP70-20-GO | 20 (40 μL) | 200 μL |  |
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| ZAP70-20-GR | 20 (40 μL) | 200 μL |  |
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| ZAP70-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : ZAP70
Gene Name : Zeta chain of T-cell receptor associated protein kinase 70
Chromosome : CHR 2: 977,120,29-977,443,26
Locus : 2q11.2
Alt. Genes : DHRS2
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