This locus represents a highly conserved functional element that is located in an intron of the limb development membrane protein 1 gene. In the developing limb bud, this element functions as a long-range enhancer of the sonic hedgehog gene, which is located approximately 1 Mb downstream. Mutations in this element disrupt limb patterning and can result in a range of congenital limb malformations, including preaxial polydactyly, triphalangeal thumbs, Werner mesomelic syndrome (WMS), polysyndactyly, or Laurin-Sandrow syndrome. [provided by RefSeq, Nov 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ZRS-20-RE | 20 (40 μL) | 200 μL |  |
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| ZRS-20-OR | 20 (40 μL) | 200 μL |  |
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| ZRS-20-GO | 20 (40 μL) | 200 μL |  |
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| ZRS-20-GR | 20 (40 μL) | 200 μL |  |
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| ZRS-20-AQ | 20 (40 μL) | 200 μL |  |
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This locus represents a highly conserved functional element that is located in an intron of the limb development membrane protein 1 gene. In the developing limb bud, this element functions as a long-range enhancer of the sonic hedgehog gene, which is located approximately 1 Mb downstream. Mutations in this element disrupt limb patterning and can result in a range of congenital limb malformations, including preaxial polydactyly, triphalangeal thumbs, Werner mesomelic syndrome (WMS), polysyndactyly, or Laurin-Sandrow syndrome. [provided by RefSeq, Nov 2015]
Gene Symbol : ZRS
Gene Name : ZPA regulatory sequence
Chromosome : CHR 7: 0-0
Locus : 7q
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