Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ACTN2BA-20-REGO | 20 (40 μL) | 200 μL |
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| ACTN2BA-20-REGR | 20 (40 μL) | 200 μL |
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| ACTN2BA-20-ORGR | 20 (40 μL) | 200 μL |
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| ACTN2BA-20-GOGR | 20 (40 μL) | 200 μL |
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| ACTN2BA-20-GRRE | 20 (40 μL) | 200 μL |
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| ACTN2BA-20-GROR | 20 (40 μL) | 200 μL |
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| ACTN2BA-20-GRGO | 20 (40 μL) | 200 μL |
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| ACTN2BA-20-AQOR | 20 (40 μL) | 200 μL |
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Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
Gene Symbol : ACTN2
Gene Name : Actinin alpha 2
Chromosome : CHR 1: 236,686,453-236,764,630
Locus : 1q43
Alt. Genes : CELA3A
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