This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ALPLBA-20-REGO | 20 (40 μL) | 200 μL |
|
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| ALPLBA-20-REGR | 20 (40 μL) | 200 μL |
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| ALPLBA-20-ORGR | 20 (40 μL) | 200 μL |
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| ALPLBA-20-GOGR | 20 (40 μL) | 200 μL |
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| ALPLBA-20-GRRE | 20 (40 μL) | 200 μL |
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| ALPLBA-20-GROR | 20 (40 μL) | 200 μL |
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| ALPLBA-20-GRGO | 20 (40 μL) | 200 μL |
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| ALPLBA-20-AQOR | 20 (40 μL) | 200 μL |
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This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]
Gene Symbol : ALPL
Gene Name : Alkaline phosphatase, liver/bone/kidney
Chromosome : CHR 1: 215,089,81-215,784,11
Locus : 1p36.12
Alt. Genes : G3BP1
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