This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| APAF1BA-20-REGO | 20 (40 μL) | 200 μL |
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| APAF1BA-20-REGR | 20 (40 μL) | 200 μL |
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| APAF1BA-20-ORGR | 20 (40 μL) | 200 μL |
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| APAF1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| APAF1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| APAF1BA-20-GROR | 20 (40 μL) | 200 μL |
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| APAF1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| APAF1BA-20-AQOR | 20 (40 μL) | 200 μL |
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This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Symbol : APAF1
Gene Name : Apoptotic peptidase activating factor 1
Chromosome : CHR 12: 986,451,40-987,354,32
Locus : 12q23.1
Alt. Genes : LRPPRC
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