The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CASP3BA-20-REGO | 20 (40 μL) | 200 μL |
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| CASP3BA-20-REGR | 20 (40 μL) | 200 μL |
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| CASP3BA-20-ORGR | 20 (40 μL) | 200 μL |
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| CASP3BA-20-GOGR | 20 (40 μL) | 200 μL |
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| CASP3BA-20-GRRE | 20 (40 μL) | 200 μL |
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| CASP3BA-20-GROR | 20 (40 μL) | 200 μL |
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| CASP3BA-20-GRGO | 20 (40 μL) | 200 μL |
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| CASP3BA-20-AQOR | 20 (40 μL) | 200 μL |
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The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
Gene Symbol : CASP3
Gene Name : Caspase 3
Chromosome : CHR 4: 184,649,474-184,627,695
Locus : 4q35.1
Alt. Genes : RBM12
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