This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CENPFBA-20-REGO | 20 (40 μL) | 200 μL |
|
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| CENPFBA-20-REGR | 20 (40 μL) | 200 μL |
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| CENPFBA-20-ORGR | 20 (40 μL) | 200 μL |
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| CENPFBA-20-GOGR | 20 (40 μL) | 200 μL |
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| CENPFBA-20-GRRE | 20 (40 μL) | 200 μL |
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| CENPFBA-20-GROR | 20 (40 μL) | 200 μL |
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| CENPFBA-20-GRGO | 20 (40 μL) | 200 μL |
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| CENPFBA-20-AQOR | 20 (40 μL) | 200 μL |
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This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]
Gene Symbol : CENPF
Gene Name : Centromere protein F
Chromosome : CHR 1: 214,603,180-214,664,573
Locus : 1q41
Alt. Genes : FEM1B
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