This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CFL2BA-20-REGO | 20 (40 μL) | 200 μL |
|
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| CFL2BA-20-REGR | 20 (40 μL) | 200 μL |
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| CFL2BA-20-ORGR | 20 (40 μL) | 200 μL |
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| CFL2BA-20-GOGR | 20 (40 μL) | 200 μL |
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| CFL2BA-20-GRRE | 20 (40 μL) | 200 μL |
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| CFL2BA-20-GROR | 20 (40 μL) | 200 μL |
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| CFL2BA-20-GRGO | 20 (40 μL) | 200 μL |
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| CFL2BA-20-AQOR | 20 (40 μL) | 200 μL |
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This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Gene Symbol : CFL2
Gene Name : Cofilin 2
Chromosome : CHR 14: 347,148,22-347,103,81
Locus : 14q13.1
Alt. Genes : CELA3A
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