Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CHIT1BA-20-REGO | 20 (40 μL) | 200 μL |
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| CHIT1BA-20-REGR | 20 (40 μL) | 200 μL |
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| CHIT1BA-20-ORGR | 20 (40 μL) | 200 μL |
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| CHIT1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| CHIT1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| CHIT1BA-20-GROR | 20 (40 μL) | 200 μL |
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| CHIT1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| CHIT1BA-20-AQOR | 20 (40 μL) | 200 μL |
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Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]
Gene Symbol : CHIT1
Gene Name : Chitinase 1
Chromosome : CHR 1: 203,229,731-203,216,078
Locus : 1q32.1
Alt. Genes : ZNF197
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