The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CNTFBA-20-REGO | 20 (40 μL) | 200 μL |
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| CNTFBA-20-REGR | 20 (40 μL) | 200 μL |
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| CNTFBA-20-ORGR | 20 (40 μL) | 200 μL |
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| CNTFBA-20-GOGR | 20 (40 μL) | 200 μL |
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| CNTFBA-20-GRRE | 20 (40 μL) | 200 μL |
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| CNTFBA-20-GROR | 20 (40 μL) | 200 μL |
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| CNTFBA-20-GRGO | 20 (40 μL) | 200 μL |
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| CNTFBA-20-AQOR | 20 (40 μL) | 200 μL |
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The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]
Gene Symbol : CNTF
Gene Name : Ciliary neurotrophic factor
Chromosome : CHR 11: 586,226,72-586,257,32
Locus : 11q12.1
Alt. Genes : CELA3A
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