Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CSE1LBA-20-REGO | 20 (40 μL) | 200 μL |
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| CSE1LBA-20-REGR | 20 (40 μL) | 200 μL |
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| CSE1LBA-20-ORGR | 20 (40 μL) | 200 μL |
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| CSE1LBA-20-GOGR | 20 (40 μL) | 200 μL |
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| CSE1LBA-20-GRRE | 20 (40 μL) | 200 μL |
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| CSE1LBA-20-GROR | 20 (40 μL) | 200 μL |
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| CSE1LBA-20-GRGO | 20 (40 μL) | 200 μL |
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| CSE1LBA-20-AQOR | 20 (40 μL) | 200 μL |
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Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Symbol : CSE1L
Gene Name : Chromosome segregation 1 like
Chromosome : CHR 20: 490,462,45-490,969,59
Locus : 20q13.13
Alt. Genes : ENAM
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