This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CTLA4BA-20-REGO | 20 (40 μL) | 200 μL |
|
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| CTLA4BA-20-REGR | 20 (40 μL) | 200 μL |
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| CTLA4BA-20-ORGR | 20 (40 μL) | 200 μL |
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| CTLA4BA-20-GOGR | 20 (40 μL) | 200 μL |
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| CTLA4BA-20-GRRE | 20 (40 μL) | 200 μL |
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| CTLA4BA-20-GROR | 20 (40 μL) | 200 μL |
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| CTLA4BA-20-GRGO | 20 (40 μL) | 200 μL |
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| CTLA4BA-20-AQOR | 20 (40 μL) | 200 μL |
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This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
Gene Symbol : CTLA4
Gene Name : Cytotoxic T-lymphocyte associated protein 4
Chromosome : CHR 2: 203,867,787-203,873,959
Locus : 2q33.2
Alt. Genes : PLXNC1
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