This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CTTNBA-20-REGO | 20 (40 μL) | 200 μL |
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| CTTNBA-20-REGR | 20 (40 μL) | 200 μL |
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| CTTNBA-20-ORGR | 20 (40 μL) | 200 μL |
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| CTTNBA-20-GOGR | 20 (40 μL) | 200 μL |
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| CTTNBA-20-GRRE | 20 (40 μL) | 200 μL |
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| CTTNBA-20-GROR | 20 (40 μL) | 200 μL |
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| CTTNBA-20-GRGO | 20 (40 μL) | 200 μL |
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| CTTNBA-20-AQOR | 20 (40 μL) | 200 μL |
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This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
Gene Symbol : CTTN
Gene Name : Cortactin
Chromosome : CHR 11: 703,985,05-704,365,83
Locus : 11q13.3
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