This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias. [provided by RefSeq, Jan 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CYB5R3BA-20-REGO | 20 (40 μL) | 200 μL |
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| CYB5R3BA-20-REGR | 20 (40 μL) | 200 μL |
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| CYB5R3BA-20-ORGR | 20 (40 μL) | 200 μL |
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| CYB5R3BA-20-GOGR | 20 (40 μL) | 200 μL |
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| CYB5R3BA-20-GRRE | 20 (40 μL) | 200 μL |
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| CYB5R3BA-20-GROR | 20 (40 μL) | 200 μL |
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| CYB5R3BA-20-GRGO | 20 (40 μL) | 200 μL |
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| CYB5R3BA-20-AQOR | 20 (40 μL) | 200 μL |
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This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias. [provided by RefSeq, Jan 2010]
Gene Symbol : CYB5R3
Gene Name : Cytochrome b5 reductase 3
Chromosome : CHR 22: 426,493,98-426,178,39
Locus : 22q13.2
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