This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DAB2BA-20-REGO | 20 (40 μL) | 200 μL |
|
Request Pricing |
| DAB2BA-20-REGR | 20 (40 μL) | 200 μL |
|
Request Pricing |
| DAB2BA-20-ORGR | 20 (40 μL) | 200 μL |
|
Request Pricing |
| DAB2BA-20-GOGR | 20 (40 μL) | 200 μL |
|
Request Pricing |
| DAB2BA-20-GRRE | 20 (40 μL) | 200 μL |
|
Request Pricing |
| DAB2BA-20-GROR | 20 (40 μL) | 200 μL |
|
Request Pricing |
| DAB2BA-20-GRGO | 20 (40 μL) | 200 μL |
|
Request Pricing |
| DAB2BA-20-AQOR | 20 (40 μL) | 200 μL |
|
Request Pricing |
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Symbol : DAB2
Gene Name : DAB2, clathrin adaptor protein
Chromosome : CHR 5: 394,252,32-393,716,73
Locus : 5p13.1
Alt. Genes : ARPC2
Lorem Ipsum is simply dummy text of the printing and typesetting industry.
Lorem Ipsum is simply dummy text of the printing and typesetting industry.