This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DNASE1BA-20-REGO | 20 (40 μL) | 200 μL |
|
Request Pricing |
| DNASE1BA-20-REGR | 20 (40 μL) | 200 μL |
|
Request Pricing |
| DNASE1BA-20-ORGR | 20 (40 μL) | 200 μL |
|
Request Pricing |
| DNASE1BA-20-GOGR | 20 (40 μL) | 200 μL |
|
Request Pricing |
| DNASE1BA-20-GRRE | 20 (40 μL) | 200 μL |
|
Request Pricing |
| DNASE1BA-20-GROR | 20 (40 μL) | 200 μL |
|
Request Pricing |
| DNASE1BA-20-GRGO | 20 (40 μL) | 200 μL |
|
Request Pricing |
| DNASE1BA-20-AQOR | 20 (40 μL) | 200 μL |
|
Request Pricing |
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Symbol : DNASE1
Gene Name : Deoxyribonuclease 1
Chromosome : CHR 16: 361,170,4-366,547,1
Locus : 16p13.3
Alt. Genes : HNRNPA3P1
Lorem Ipsum is simply dummy text of the printing and typesetting industry.
Lorem Ipsum is simply dummy text of the printing and typesetting industry.