This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DNM1BA-20-REGO | 20 (40 μL) | 200 μL |
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| DNM1BA-20-REGR | 20 (40 μL) | 200 μL |
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| DNM1BA-20-ORGR | 20 (40 μL) | 200 μL |
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| DNM1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| DNM1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| DNM1BA-20-GROR | 20 (40 μL) | 200 μL |
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| DNM1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| DNM1BA-20-AQOR | 20 (40 μL) | 200 μL |
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This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Symbol : DNM1
Gene Name : Dynamin 1
Chromosome : CHR 9: 128,203,354-128,255,247
Locus : 9q34.11
Alt. Genes : OPTN
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