The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DPYDBA-20-REGO | 20 (40 μL) | 200 μL |
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| DPYDBA-20-REGR | 20 (40 μL) | 200 μL |
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| DPYDBA-20-ORGR | 20 (40 μL) | 200 μL |
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| DPYDBA-20-GOGR | 20 (40 μL) | 200 μL |
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| DPYDBA-20-GRRE | 20 (40 μL) | 200 μL |
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| DPYDBA-20-GROR | 20 (40 μL) | 200 μL |
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| DPYDBA-20-GRGO | 20 (40 μL) | 200 μL |
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| DPYDBA-20-AQOR | 20 (40 μL) | 200 μL |
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The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Symbol : DPYD
Gene Name : Dihydropyrimidine dehydrogenase
Chromosome : CHR 1: 979,210,58-970,777,42
Locus : 1p21.3
Alt. Genes : OPTN
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