This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DSC2BA-20-REGO | 20 (40 μL) | 200 μL |
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| DSC2BA-20-REGR | 20 (40 μL) | 200 μL |
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| DSC2BA-20-ORGR | 20 (40 μL) | 200 μL |
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| DSC2BA-20-GOGR | 20 (40 μL) | 200 μL |
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| DSC2BA-20-GRRE | 20 (40 μL) | 200 μL |
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| DSC2BA-20-GROR | 20 (40 μL) | 200 μL |
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| DSC2BA-20-GRGO | 20 (40 μL) | 200 μL |
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| DSC2BA-20-AQOR | 20 (40 μL) | 200 μL |
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This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Gene Symbol : DSC2
Gene Name : Desmocollin 2
Chromosome : CHR 18: 311,024,31-310,659,73
Locus : 18q12.1
Alt. Genes : PLXNC1
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