This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DSG1BA-20-REGO | 20 (40 μL) | 200 μL |
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| DSG1BA-20-REGR | 20 (40 μL) | 200 μL |
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| DSG1BA-20-ORGR | 20 (40 μL) | 200 μL |
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| DSG1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| DSG1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| DSG1BA-20-GROR | 20 (40 μL) | 200 μL |
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| DSG1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| DSG1BA-20-AQOR | 20 (40 μL) | 200 μL |
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This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]
Gene Symbol : DSG1
Gene Name : Desmoglein 1
Chromosome : CHR 18: 313,180,88-313,592,45
Locus : 18q12.1
Alt. Genes : AASS
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